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Cu-Catalyzed Deoxygenative C2-Sulfonylation Reaction of Quinoline N‑Oxides with Sodium Sulfinate

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journal contribution
posted on 10.08.2016, 13:45 by Bingnan Du, Ping Qian, Yang Wang, Haibo Mei, Jianlin Han, Yi Pan
An unexpected Cu-catalyzed deoxygenative C2-sulfonylation reaction of quinoline N-oxides in the presence of radical initiator K2S2O8 was developed that used sodium sulfinate as a sulfonyl coupling partner. The mechanism studies indicate that the reaction proceeds via Minisci-like radical coupling step to give sulfonylated quinoline with good chemical yields.