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Cu-Catalyzed Dehydrogenative Olefinsulfonation of Alkyl Arenes

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journal contribution
posted on 12.11.2020, 02:13 by Fangfang Li, Guang’an Zhang, Yingguo Liu, Bingke Zhu, Yuting Leng, Junliang Wu
A copper-catalyzed reaction protocol for the dehydrogenation of ethylbenzenes into styrene derivatives has been developed. This reaction procedure proceeded well under mild reaction conditions, providing a practical and efficient strategy for the rapid assembly of biologically and pharmaceutically significant molecules, such as vinyl sulfone. Simple alkyl arenes were functionalized via consecutive β-elimination in the presence of N-sulfonylbenzo­[d]­imidazole with broad substrate scope and good functional group tolerance.