posted on 2024-02-09, 00:29authored byXiao-Fang Song, Li-Jing Zhang, Xing-Guo Zhang, Hai-Yong Tu
A practical
and efficient copper-catalyzed carbocyclization of
2-functionalized anilines with ethyl bromodifluoroacetate has been
developed. Ethyl bromodifluoroacetate is employed as the C1 source
via quadruple cleavage in this transformation. This reaction can afford
a variety of N-containing heterocyclics with satisfactory
yields and excellent functional group compatibility.