Cross-Coupling of Acrylamides and Maleimides under Rhodium Catalysis: Controlled Olefin Migration
journal contributionposted on 16.05.2016, 18:35 by Satyasheel Sharma, Sang Hoon Han, Yongguk Oh, Neeraj Kumar Mishra, Suk Hun Lee, Joa Sub Oh, In Su Kim
The rhodium(III)-catalyzed direct cross-coupling reaction of electron-deficient acrylamides with maleimides is described. This protocol displays broad functional group tolerance and high efficiency, which offers a new opportunity to access highly substituted succinimides. Dependent on the substituent positions of acrylamides and reaction conditions, olefin migrated products were obtained with high regio- and stereoselectivity.