American Chemical Society
ol400378v_si_001.pdf (1.92 MB)

Creation of Highly Congested Quaternary Centers via Cu-catalyzed Conjugate Addition of Alkenyl Alanates to β‑Substituted Cyclic Enones

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journal contribution
posted on 2013-04-05, 00:00 authored by Daniel Müller, Alexandre Alexakis
Easily prepared alkenylalanates proved to be excellent nucleophiles for the creation of highly congested quaternary centers via copper-catalyzed conjugate addition. In addition, functionalized cis-decaline systems can now be prepared in a simple two-step sequence involving Cu-catalyzed conjugate addition with functionalized alkenylalanates.