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Cp*Co(III)-Catalyzed C–H Alkylation with Maleimides Using Weakly Coordinating Carbonyl Directing Groups

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journal contribution
posted on 07.05.2018, 20:20 by Rajib Mandal, Balakumar Emayavaramban, Basker Sundararaju
A novel protocol for ortho-C–H alkylation of aromatic and heteroaromatic ketones and esters under Cp*Co­(III) catalysis has been developed for the first time. The reaction proceeds through initial cyclometalation via weak chelation-assisted C–H bond activation, followed by coordination of activated alkene, insertion between Co–C, and protodemetalation.