nl6b03251_si_001.pdf (1.36 MB)
Core/Shell Nanocomposites Produced by Superfast Sequential Microfluidic Nanoprecipitation
journal contribution
posted on 2017-01-06, 00:00 authored by Dongfei Liu, Hongbo Zhang, Salvatore Cito, Jin Fan, Ermei Mäkilä, Jarno Salonen, Jouni Hirvonen, Tiina M. Sikanen, David A. Weitz, Hélder A. SantosAlthough
a number of techniques exist for generating structured
organic nanocomposites, it is still challenging to fabricate them
in a controllable, yet universal and scalable manner. In this work,
a microfluidic platform, exploiting superfast (milliseconds) time
intervals between sequential nanoprecipitation processes, has been
developed for high-throughput production of structured core/shell
nanocomposites. The extremely short time interval between the sequential
nanoprecipitation processes, facilitated by the multiplexed microfluidic
design, allows us to solve the instability issues of nanocomposite
cores without using any stabilizers. Beyond high throughput production
rate (∼700 g/day on a single device), the generated core/shell
nanocomposites harness the inherent ultrahigh drug loading degree
and enhanced payload dissolution kinetics of drug nanocrystals and
the controlled drug release from polymer-based nanoparticles.
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microfluidic platforminstability issuestime intervalsequential nanoprecipitation processesdrug nanocrystalsdrug releaseSuperfast Sequential Microfluidic Nanoprecipitationnanocomposite corespolymer-based nanoparticleshigh-throughput productionpayload dissolution kineticsscalable mannertime intervalsmultiplexed microfluidic designultrahigh drug loading degree
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