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Copper-Mediated Oxidative Trifluoromethylation of Boronic Acids

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journal contribution
posted on 05.11.2010, 00:00 by Lingling Chu, Feng-Ling Qing
A copper-mediated oxidative cross-coupling of aryl- and alkenylboronic acids with (trifluoromethyl)trimethylsilane (Me3SiCF3) under mild conditions has been developed. This method allows a wide range of functional group tolerant trifluoromethylated arenes and alkenes to be easily prepared. This oxidative trifluoromethylation has the potential to introduce trifluoromethyl groups into advanced, highly functionalized organic molecules.

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