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Copper-Mediated Oxidative Decarboxylative Coupling of Arylpropiolic Acids with Dialkyl H‑Phosphonates in Water

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journal contribution
posted on 2014-02-07, 00:00 authored by Xiang Li, Fan Yang, Yangjie Wu, Yusheng Wu
An efficient, mild, and generally applicable protocol for copper-mediated oxidative decarboxylative coupling of arylpropiolic acids with dialkyl H-phosphonates in water has been developed. Note that the reaction could proceed smoothly under air at relatively low temperature (60 °C), and the addition of isopropanol could successfully suppress the decomposition of dialkyl H-phosphonates in water.