posted on 2016-02-21, 14:20authored byQingqing Qi, Qilong Shen, Long Lu
A Cu-mediated ligandless aerobic fluoroalkylation
of arylboronic
acids under mild conditions is described for the first time. The reaction
tolerates a wide range of functional groups, allowing for further
transformation. Mechanistic studies suggest that [RfCu]
is the active Cu species that forms the desired perfluoroalkylarenes
and that [RfCu] is generated from [PhCu] by either an oxidative
addition/reductive elimination mechanism or nucleophilic substitution
via a halogen “ate” intermediate.