jo501162s_si_001.pdf (14.01 MB)
Copper(I) Bromide Catalyzed Arylation of Cyclic Enamides and Naphthyl-1-acetamides Using Diaryliodonium Salts
journal contributionposted on 2014-09-05, 00:00 authored by Muthuraj Prakash, Subramaniam Muthusamy, Venkitasamy Kesavan
Copper(I) bromide catalyzed direct C–H arylation of cyclic enamides was achieved using diaryliodonium salts in the absence of base/additive at ambient temperature with high yields. A biologically active dihydro[a]benzocarbazole scaffold was synthesized using the established protocol. The scope of the current methodology was further extended for the synthesis of C4-, C7-aryl-substituted 1-naphthyl acetamides in good yields.