ol9b02733_si_001.pdf (5.08 MB)

Copper(I)-Catalyzed Oxyamination of β,γ-Unsaturated Hydrazones: Synthesis of Dihydropyrazoles

Download (5.08 MB)
journal contribution
posted on 20.09.2019, 15:39 by Shanshan Chen, Wenming Chen, Xu Chen, Guifang Chen, Lutz Ackermann, Xu Tian
An efficient aerobic copper­(I)-catalyzed oxyamination of β,γ-unsaturated hydrazones has been developed. The methodology provides effective access to dihydropyrazole derivatives in a one-pot process utilizing dioxygen as a sustainable sacrificial oxidant. Mechanistic studies have been performed and are suggestive of an aerobic manifold via single electron transfer.