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Copper(I)-Catalyzed Oxyamination of β,γ-Unsaturated Hydrazones: Synthesis of Dihydropyrazoles

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journal contribution
posted on 20.09.2019, 15:39 by Shanshan Chen, Wenming Chen, Xu Chen, Guifang Chen, Lutz Ackermann, Xu Tian
An efficient aerobic copper­(I)-catalyzed oxyamination of β,γ-unsaturated hydrazones has been developed. The methodology provides effective access to dihydropyrazole derivatives in a one-pot process utilizing dioxygen as a sustainable sacrificial oxidant. Mechanistic studies have been performed and are suggestive of an aerobic manifold via single electron transfer.

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