Copper(II)-Catalyzed Enantioselective Intramolecular
Cyclization of N‑Alkenylureas

Fu, Shaomin; Yang, Honghao; Li, Guoqiang; Deng, Yuanfu; Jiang, Huanfeng; Zeng, Wei

doi:10.1021/acs.orglett.5b00131.s001

Copper(II)-Catalyzed Enantioselective Intramolecular Cyclization of N‑Alkenylureas

journal contribution

posted on 2015-02-20, 00:00 authored by Shaomin Fu, Honghao Yang, Guoqiang Li, Yuanfu Deng, Huanfeng Jiang, Wei Zeng

The first Cu(II)-catalyzed highly enantioselective intramolecular cyclization of N-alkenylureas was developed for the concise assembly of chiral vicinal diamino bicyclic heterocycles. Facile removal of carbonyl group of the carbamido moiety allowed for ready access to enantioenriched cyclic vicinal diamines.