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Copper(II)-Catalyzed Direct Sulfonylation of C(sp2)–H Bonds with Sodium Sulfinates

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journal contribution
posted on 05.06.2015, 00:00 by Wei-Hao Rao, Bing-Feng Shi
A copper-catalyzed direct sulfonylation of C­(sp2)–H bonds with sodium sulfinates using a removable directing group is described. This reaction tolerates a wide range of functional groups, providing an efficient protocol for the synthesis of diverse aryl sulfones. Moreover, a series of 2,6-disubstituted benzamides could be synthesized via sequential C–H functionalization.