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Copper(II)-Catalyzed Carbon–Carbon Triple Bond Cleavage of Internal Alkynes for the Synthesis of Annulated Indolizines

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journal contribution
posted on 02.05.2014, 00:00 by Jinwei Sun, Fuyao Wang, Huayou Hu, Xiangshan Wang, Hui Wu, Yun Liu
Cleavage of CC bond in butynedioates via copper­(II)-catalyzed reaction has been achieved, leading to the synthesis of benzo­[f]­pyrido­[1,2-a]­indole-6,11-diones in high yields by one-pot three-component reactions. In this unprecedented CC bond cleavage reaction of internal alkynes, both fragments from the alkyne are successively incorporated into the products.