Copper Complexes as Bioinspired Models for Lytic Polysaccharide Monooxygenases
journal contributionposted on 2017-01-06, 17:36 authored by Alda Lisa Concia, Maria Rosa Beccia, Maylis Orio, Francine Terra Ferre, Marciela Scarpellini, Frédéric Biaso, Bruno Guigliarelli, Marius Réglier, A. Jalila Simaan
We report here two copper complexes as first functional models for lytic polysaccharide monooxygenases, mononuclear copper-containing enzymes involved in recalcitrant polysaccharide breakdown. These complexes feature structural and spectroscopic properties similar to those of the enzyme. In addition, they catalyze oxidative cleavage of the model substrate p-nitrophenyl-β-d-glucopyranoside. More importantly, a particularly stable copper(II) hydroperoxide intermediate is detected in the reaction conditions.
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reaction conditionsBioinspired Modelsspectroscopic propertiesLytic Polysaccharide Monooxygenasescomplexes featureCopper Complexesnitrophenyl -β-dpolysaccharide breakdownhydroperoxidemodel substrate pcopper complexescatalyze oxidative cleavagelytic polysaccharide monooxygenasescopper-containing enzymes