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Copper-Catalyzed Tandem Azide–Alkyne Cycloaddition, Ullmann Type C–N Coupling, and Intramolecular Direct Arylation

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journal contribution
posted on 18.02.2016, 22:52 authored by Kasiviswanadharaju Pericherla, Amitabh Jha, Bharti Khungar, Anil Kumar
A ligand-free copper-catalyzed tandem azide–alkyne cycloaddition (CuAAC), Ullmann-type C–N coupling, and intramolecular direct arylation has been described. The designed strategy resulted in the synthesis of a novel trazole-fused azaheterocycle framework. The reaction gave good yields (59–77%) of 1,2,3-triazole-fused imidazo[1,2-a]pyridines in a single step.

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