American Chemical Society
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Copper-Catalyzed Synthesis of Enantioenriched Tetraarylethanes

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journal contribution
posted on 2008-03-06, 00:00 authored by Wendy S. Jen, Matthew D. Truppo, Deborah Amos, Paul Devine, Michael McNevin, Mirlinda Biba, Kevin R. Campos
Herein we report the asymmetric synthesis of 1,2-dipyridyl-1,2-diarylethanes via an unusual Cu(I)-catalyzed dimerization reaction. Subjection of a variety of enantioenriched substituted 2-pyridyl alcohols to a one-pot protocol generates the desired products in good yields and diastereoselectivities and with ee's up to >99%.