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Copper-Catalyzed Regioselective Trifluoro­methyl­thiolation of Pyrroles by Trifluoro­methane­sulfonyl Hypervalent Iodonium Ylide

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journal contribution
posted on 06.03.2015, 00:00 by Zhongyan Huang, Yu-Dong Yang, Etsuko Tokunaga, Norio Shibata
The copper-catalyzed tri­fluoro­methyl­thiolation of pyrroles with a trifluoro­methane­sulfonyl hypervalent iodonium ylide under mild conditions has been achieved. A broad set of pyrroles could be transformed to the corresponding products in moderate to excellent yields. The reaction mechanism is hypothesized.