posted on 2015-12-18, 00:00authored byXuan-Hui Ouyang, Ren-Jie Song, Yu Liu, Ming Hu, Jin-Heng Li
A novel
selective copper-catalyzed radical [2 + 2 + 1] annulation
of benzene-linked 1,n-enynes with azido-benziodoxolone
to access fused pyrroline compounds, including 3H-pyrrolo[3,4-c]quinolin-4(3aH)-ones, chromeno[3,4-c]pyrrol-4(9bH)-one, and indeno[1,2-c]pyrroline,
has been developed, which proceeds via the addition of the azide radical
to the alkene, annualtion, and azidation cascade.