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Copper-Catalyzed Radical [2 + 2 + 1] Annulation of Benzene-Linked 1,n‑Enynes with Azide: Fused Pyrroline Compounds

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posted on 2015-12-18, 00:00 authored by Xuan-Hui Ouyang, Ren-Jie Song, Yu Liu, Ming Hu, Jin-Heng Li
A novel selective copper-catalyzed radical [2 + 2 + 1] annulation of benzene-linked 1,n-enynes with azido-benziodoxolone to access fused pyrroline compounds, including 3H-pyrrolo­[3,4-c]­quinolin-4­(3aH)-ones, chromeno­[3,4-c]­pyrrol-4­(9bH)-one, and indeno­[1,2-c]­pyrroline, has been developed, which proceeds via the addition of the azide radical to the alkene, annualtion, and azidation cascade.

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