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Copper-Catalyzed Oxidative Direct Cyclization of N-Methylanilines with Electron-Deficient Alkenes Using Molecular Oxygen

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journal contribution
posted on 05.08.2011, 00:00 by Mayuko Nishino, Koji Hirano, Tetsuya Satoh, Masahiro Miura
The oxidative direct cyclizaion of N-methylanilines with electron-deficient alkenes involving maleimides and benzylidene malononitriles through sp3 and sp2 C–H bond cleavage proceeds effectively under a CuCl2/O2 catalysis to provide the corresponding tetrahydroquinolines in good yields.