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Copper-Catalyzed Oxidative C–H Amination of Tetrahydrofuran with Indole/Carbazole Derivatives

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journal contribution
posted on 06.11.2015, 00:00 by Qingjing Yang, Pui Ying Choy, Wai Chung Fu, Baomin Fan, Fuk Yee Kwong
A simple α-C–H amination of cyclic ether with indole/carbazole derivatives has been accomplished by employing copper­(II) chloride/bipy as the catalyst system. In the presence of the di-tert-butyl peroxide oxidant, cyclic ethers such as tetrahydrofuran, 1,4-dioxane, and tetrahydropyran successfully undergo C–H/N–H cross dehydrogenative coupling (CDC) with various carbazole or indole derivatives in good-to-excellent yields.

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