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Copper-Catalyzed Oxidative Amination of sp3 C–H Bonds under Air: Synthesis of 1,3-Diarylated Imidazo[1,5‑a]pyridines

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journal contribution
posted on 20.02.2015, 00:00 by Huiqiao Wang, Wentao Xu, Zhiqiang Wang, Lintao Yu, Kun Xu
A copper­(II)-catalyzed tandem reaction between pyridine ketone and benzylamine was developed by using clean O2 as an oxidant. This transformation proceeded via an efficient condensation–amination–oxidative dehydrogenation process, affording 1,3-diarylated imidazo­[1,5-a]­pyridines in excellent yields.