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Copper-Catalyzed Enantioselective Propargylic Amination of Nonaromatic Propargylic Esters with Amines

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journal contribution
posted on 2011-05-06, 00:00 authored by Akiko Yoshida, Gaku Hattori, Yoshihiro Miyake, Yoshiaki Nishibayashi
The enantioselective propargylic amination of propargylic pentafluorobenzoates bearing an alkyl group at the propargylic position with amines in the presence of catalytic amounts of a copper complex and an optically active diphosphine such as BINAP has been found to give the corresponding propargylic amines in good yields with high enantioselectivity.

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