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Copper Catalyzed β‑Difluoroacetylation of Dihydropyrans and Glycals by Means of Direct C–H Functionalization

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journal contribution
posted on 05.07.2013, 00:00 by Marie-Charlotte Belhomme, Thomas Poisson, Xavier Pannecoucke
A copper catalyzed direct functionalization of dihydropyrans and glycals has been developed. This method affords a new and straightforward access to C-2-CF2 dihydropyrans and glycosides in a single step starting from readily available starting materials. This new copper based catalytic system, probably involving a Cu(III) species as supported by experiments, allows the formation of the valuable fluorinated glycosides in good yields.