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Copper-Catalyzed Cascade Transformation of O‑Propargylic Oximes with Sulfonyl Azides to α,β-Unsaturated N‑Acylamidines

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journal contribution
posted on 03.10.2014, 00:00 by Dong Zhang, Itaru Nakamura, Masahiro Terada
Copper-catalyzed cascade transformations of O-propargylic oximes and sulfonyl azides were carried out to efficiently afford α,β-unsaturated N-acylamidines. The reaction involved the intramolecular attack of the oxime group to the ketenimine moiety that was generated in situ, followed by the cleavage of the N–O bond.