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Copper Catalyzed C−H Functionalization for Direct Mannich Reactions

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journal contribution
posted on 04.03.2011, 00:00 by Magnus Rueping, Nikita Tolstoluzhsky
A protocol for a practical and direct addition of α- and γ-alkyl azaarenes to N-sulfonyl aldimines has been developed. Copper salts act as efficient Lewis acid catalysts for direct Mannich-type reactions providing a mild and fast access to various functionalized heterocycles.