Copper Catalyzed C−H Functionalization for Direct Mannich Reactions
journal contributionposted on 04.03.2011 by Magnus Rueping, Nikita Tolstoluzhsky
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A protocol for a practical and direct addition of α- and γ-alkyl azaarenes to N-sulfonyl aldimines has been developed. Copper salts act as efficient Lewis acid catalysts for direct Mannich-type reactions providing a mild and fast access to various functionalized heterocycles.