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Copper-Catalyzed Aerobic Oxidative Amidation of Terminal Alkynes:  Efficient Synthesis of Ynamides

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journal contribution
posted on 23.01.2008, 00:00 authored by Tetsuya Hamada, Xuan Ye, Shannon S. Stahl
A copper-catalyzed method for the preparation of ynamides has been identified that proceeds via aerobic oxidative coupling of terminal alkynes with various nitrogen nucleophiles, including cyclic carbamates, amides and ureas, and N-alkyl-arylsulfonamides and indoles.