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Copper-Catalyzed Aerobic Aliphatic C–H Oxygenation Directed by an Amidine Moiety

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journal contribution
posted on 2012-07-25, 00:00 authored by Yi-Feng Wang, Hui Chen, Xu Zhu, Shunsuke Chiba
A method for the oxygenation of tertiary C–H bonds of N-alkylamidines and N-(2-alkylaryl)­amidines is described that utilizes the CuBr·SMe2/2,2′-bipyridine catalytic system under an O2 atmosphere and provides dihydrooxazoles and 4H-1,3-benzoxazines. The oxygen atom is incorporated from atmospheric molecular oxygen during the present process.

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