ol9b02295_si_001.pdf (6.06 MB)
Download file

Copper-Catalyzed Three-Component Reaction of Alkynes, TMSN3, and Ethers: Regiocontrollable Synthesis of N1- and N2‑Oxyalkylated 1,2,3-Triazoles

Download (6.06 MB)
journal contribution
posted on 2019-09-03, 20:14 authored by Pengli Bao, Huilan Yue, Na Meng, Xiaohui Zhao, Jiangsheng Li, Wei Wei
A new copper-catalyzed selective synthesis of N1- and N2-oxyalkylated 1,2,3-triazoles has been developed through a three-component reaction of alkynes, TMSN3, and ethers. Through this methodology, a series of N1- and N2-oxyalkylated 1,2,3-triazoles could be efficiently and regioselectively obtained from simple and readily available starting materials with favorable functional group tolerance.