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Download fileCopper-Catalyzed Three-Component Reaction of Alkynes, TMSN3, and Ethers: Regiocontrollable Synthesis of N1- and N2‑Oxyalkylated 1,2,3-Triazoles
journal contribution
posted on 2019-09-03, 20:14 authored by Pengli Bao, Huilan Yue, Na Meng, Xiaohui Zhao, Jiangsheng Li, Wei WeiA new copper-catalyzed
selective synthesis of N1- and
N2-oxyalkylated 1,2,3-triazoles has been developed through
a three-component reaction of alkynes, TMSN3, and ethers.
Through this methodology, a series of N1- and N2-oxyalkylated 1,2,3-triazoles could be efficiently and regioselectively
obtained from simple and readily available starting materials with
favorable functional group tolerance.