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Copper-Catalyzed Three-Component Reaction of Alkynes, TMSN3, and Ethers: Regiocontrollable Synthesis of N1- and N2‑Oxyalkylated 1,2,3-Triazoles

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journal contribution
posted on 03.09.2019, 20:14 authored by Pengli Bao, Huilan Yue, Na Meng, Xiaohui Zhao, Jiangsheng Li, Wei Wei
A new copper-catalyzed selective synthesis of N1- and N2-oxyalkylated 1,2,3-triazoles has been developed through a three-component reaction of alkynes, TMSN3, and ethers. Through this methodology, a series of N1- and N2-oxyalkylated 1,2,3-triazoles could be efficiently and regioselectively obtained from simple and readily available starting materials with favorable functional group tolerance.

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