posted on 2023-11-29, 14:34authored byYong-Jie Kuang, Yan Yu, Min Zhou, Yu-Cheng Yin, Tian Cai, Qun-Li Luo
A novel protocol has been developed for the Cu-catalyzed
synthesis
of primary arylamines with meta-substituents using
cyclohexenone oxime esters. Mechanistic insights suggest that the
reaction proceeds via an intermolecular 1,5-H hydrogen
atom transfer of an imine radical intermediate. This approach features
high efficiency, a readily available catalyst system, and broad functional
group tolerance.