Copper-Catalyzed Regioselective C‑H Sulfonyloxylation of Electron-Rich Arenes with p‑Toluenesulfonic Acid and Sulfonyloxylation of Aryl(mesityl)iodonium Sulfonates
journal contributionposted on 2017-02-23, 00:00 authored by He Huang, Yang Wu, Wen Zhang, Chun Feng, Bi-Qin Wang, Wan-Fei Cai, Ping Hu, Ke-Qing Zhao, Shi-Kai Xiang
Copper-catalyzed regioselective C-H sulfonyloxylation of electron-rich arenes with p-toluenesulfonic acid has been developed. Electron-rich benzene derivatives and heteroarenes can undergo this C-H sulfonyloxylation reaction to generate aryl tosylates. Furthermore, sulfonyloxylation of aryl(mesityl)iodonium sulfonates has also been investigated. Both aryl(mesityl)iodonium tosylates and triflates can react smoothly to get aryl sulfonates. The formed aryl sulfonates can be converted to phenols, as well as used as good partners of cross-coupling reactions.