Copper-Catalyzed Perfluoroalkylation of Allyl Phosphates with Stable Perfluoroalkylzinc Reagents
journal contributionposted on 07.12.2018, 00:00 by Lihua Liu, Xifei Bao, Hua Xiao, Junlan Li, Feifan Ye, Chaoqin Wang, Qinhua Cai, Shilu Fan
A general and practical method for copper-catalyzed cross-coupling of allyl phosphates with stable perfluoroalkylzinc reagents has been developed. The reaction proceeds under mild reaction conditions with high efficiency, good functional group tolerance, and high regio- and stereoselectivities and provides general, straightforward, and useful access to allyl-perfluoroalkyl compounds. Preliminary mechanistic studies reveal that the allyl copper intermediate may be involved in the catalytic cycle.
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reaction conditionsCopper-Catalyzed Perfluoroalkylationallyl phosphatesaccessstereoselectivitiePreliminaryallyl-perfluoroalkyl compoundsmethodreaction proceedsperfluoroalkylzinc reagentsregioAllyl Phosphatescopper-catalyzed cross-couplinggroup toleranceefficiencyallyl copperStable Perfluoroalkylzinc Reagents