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Copper-Catalyzed Coupling of Acyl Chlorides with gem-Difluorinated Organozinc Reagents via Acyl Dithiocarbamates

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journal contribution
posted on 27.11.2017, 00:00 by Salavat S. Ashirbaev, Vitalij V. Levin, Marina I. Struchkova, Alexander D. Dilman
A cross-coupling of acyl chlorides with gem-difluorinated organozinc reagents affording difluorinated ketones is described. In the reaction, acyl chlorides are first treated with potassium dithiocarbamate to generate S-acyl dithiocarbamates, which couple with organozincs in the presence of a copper­(I) catalyst.