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Copper-Catalyzed Borylative Multicomponent Synthesis of Quaternary α‑Amino Esters

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journal contribution
posted on 09.01.2019, 00:00 by Kay Yeung, Fabien J. T. Talbot, Gareth P. Howell, Alexander P. Pulis, David J. Procter
Copper-catalyzed coupling of readily available ketiminoesters, allenes, and a diboron affords densely functionalized quaternary α-amino esters bearing adjacent stereocenters and versatile vinyl boronate motifs. The method utilizes a commercially available copper­(I) catalyst, operates at ambient temperature, and features a catalytic allyl cupration of ketiminoesters.

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