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Copper-Catalyzed Amino-oxymethylation of Ynamides with N,O‑Acetals

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journal contribution
posted on 28.10.2019, 17:33 by Jianliang Yu, Guangyang Xu, Shengbiao Tang, Ying Shao, Jiangtao Sun
A copper-catalyzed 1,2-difunctionalization of ynamides has been developed by using readily available N,O-acetals as the bifunctional reagents. Importantly, contrary to the initially expected 1,2-oxy-aminomethylation reaction, an unprecedented 1,2-amino-oxymethylation has been observed. This reaction is atom-economical and tolerates a broad substrate scope, affording the difunctionalization products in good yield with unique Z configuration.