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Copper-Catalyzed Aerobic Enantioselective Cross-Dehydrogenative Coupling of N‑Aryl Glycine Esters with Terminal Alkynes

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journal contribution
posted on 06.06.2016, 20:31 by Zhiyu Xie, Xigong Liu, Lei Liu
A copper-catalyzed enantioselective cross-coupling of a Csp3–H moiety (N-aryl glycine ester) with a Csp–H component (terminal alkyne) using molecular oxygen as the terminal oxidant is described for the first time. The sustainable method provides an efficient and environmentally friendly approach to rapidly prepare a diverse array of optically active non-natural α-amino acids.