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Copper-Catalyzed [4+1+1] Annulation of Ammonium Salts and Anthranils: Synthesis of 2,3-Diaroylquinolines

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journal contribution
posted on 2024-05-16, 04:05 authored by Jia-Cheng Yang, Cheng-Wei Ma, Mao-Lin Liao, Ping-Gui Li, Liang-Hua Zou
A copper(I)-catalyzed protocol is developed for the synthesis of various 2,3-diaroylquinolines starting from achiral ammonium salts and anthranils through [4+1+1] annulation. Using copper(I) chloride as the sole catalyst, this reaction is featured with easily available starting materials, broad substrate scope, good yields and simple reaction conditions.

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