Copper-Catalyzed
1,4-Alkylarylation of 1,3-Enynes
with Ethers and Aryl Boronic Acids Enabled via C(sp3)–H
Functionalization

Lv, Yunhe; Pu, Weiya; Zhang, Le; Li, Dandan; He, Linjie; Dai, Linxia; Zhou, Yaning; Zhao, Shuaike; Chen, Fei; Zhan, Jun-Long

doi:10.1021/acs.joc.4c02207.s001

Copper-Catalyzed 1,4-Alkylarylation of 1,3-Enynes with Ethers and Aryl Boronic Acids Enabled via C(sp³)–H Functionalization

journal contribution

posted on 2025-01-18, 03:29 authored by Yunhe Lv, Weiya Pu, Le Zhang, Dandan Li, Linjie He, Linxia Dai, Yaning Zhou, Shuaike Zhao, Fei Chen, Jun-Long Zhan

Herein, we present a copper-catalyzed, three-component intermolecular 1,4-alkylarylation of 1,3-enynes with ethers and aryl boronic acids. This method, driven by α-C(sp³)–H functionalization of the oxygen atom in ethers, regioselectively produces various tetrasubstituted allenes from simple, readily available precursors. Key features include mild reaction conditions and a simple catalytic system.