American Chemical Society
cs1c05517_si_001.pdf (14.52 MB)

Cooperative N‑Heterocyclic Carbene/Nickel-Catalyzed Hydroacylation of 1,3-Dienes with Aldehydes in Water

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journal contribution
posted on 2022-01-13, 21:45 authored by Hao Liu, You-Feng Han, Zhong-Hua Gao, Chun-Lin Zhang, Congyang Wang, Song Ye
The cooperative N-heterocyclic carbene/nickel-catalyzed redox-neutral hydroacylation of 1,3-dienes with aldehydes in water was reported. A wide range of aliphatic and aromatic aldehydes were directly coupled with 1,3-dienes, providing synthetically useful β,γ-unsaturated ketones or the corresponding ketones after hydrogenation in moderate to high yields and high atom economy. This protocol first demonstrated the compatibility of NHC catalysis with nickel catalysis. Water was used as the sole solvent, which is rarely reported in a cooperative metal/organic catalytic system.