American Chemical Society
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Cooperative Host/Guest Interactions via Counterion Assisted Chelation:  Pseudorotaxanes from Supramolecular Cryptands

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journal contribution
posted on 2002-10-19, 00:00 authored by Jason W. Jones, Lev N. Zakharov, Arnold L. Rheingold, Harry W. Gibson
Addition of di- or tritopic hydrogen bond accepting anions to solutions of bis(5-hydroxymethyl-1,3-phenylene)-32-crown-10 and paraquat di(hexafluorophosphate) serves to enhance host/guest interaction. In particular, addition of Et4N+CF3COO- effectively boosts Ka 14-fold, as estimated by 1H NMR studies. Similar increases in apparent Ka values are observed upon addition of n-Bu4N+OTs-. Evidenced by crystal structures, the increased association results from chelation of the OH moieties of the crown by the di- or tritopic anions, forming supramolecular bicyclic macrocycles and stabilizing the complex in a cooperative manner.