jo300779q_si_002.pdf (8.48 MB)
Cooperative Catalysis Approach to Intramolecular Hydroacylation
journal contribution
posted on 2016-02-20, 16:40 authored by Evgeny
V. Beletskiy, Ch. Sudheer, Christopher J. DouglasPrior examples of hydroacylation to form six- and seven-membered
ring ketones require either embedded chelating groups or other substrate
design strategies to circumvent competitive aldehyde decarbonylation.
A cooperative catalysis strategy enabled intramolecular hydroacylation
of disubstituted alkenes to form seven- and six-membered rings without
requiring substrate-embedded chelating groups.