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Cooperative Catalysis: A Strategy To Synthesize Trifluoromethyl-thioesters from Aldehydes

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posted on 2018-05-21, 00:00 authored by Satobhisha Mukherjee, Tuhin Patra, Frank Glorius
A cooperative catalysis between a photoredox and a hydrogen atom transfer (HAT) catalyst has been developed to synthesize trifluoromethylthioesters from aldehydes. This reaction is mild, highly selective, operationally simple, works under redox neutral condition, and exhibits a broad substrate scope with high functional group tolerance. The synthetic utility of this method is demonstrated by the late-stage functionalization of bioactive molecules, making it amenable for drug discovery.

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