posted on 2018-05-21, 00:00authored bySatobhisha Mukherjee, Tuhin Patra, Frank Glorius
A cooperative catalysis
between a photoredox and a hydrogen atom
transfer (HAT) catalyst has been developed to synthesize trifluoromethylthioesters
from aldehydes. This reaction is mild, highly selective, operationally
simple, works under redox neutral condition, and exhibits a broad
substrate scope with high functional group tolerance. The synthetic
utility of this method is demonstrated by the late-stage functionalization
of bioactive molecules, making it amenable for drug discovery.