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Conversion of Marcfortine A to Paraherquamide A via Paraherquamide B. The First Formal Synthesis of Paraherquamide A

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journal contribution
posted on 21.03.1997, 00:00 by Byung H. Lee, Michael F. Clothier
The paraherquamides and marcfortines represent a novel class of anthelmintics. The sole structural difference between paraherquamide A and marcfortine A occurs in ring G. We synthesized paraherquamide B from marcfortine A in six steps. Paraherquamide A was then prepared from paraherquamide B in seven steps. This represents the first formal synthesis of paraherquamide A.

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