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Conversion of Carbamates to Amidosulfones and Amides. Synthesis of the [14C]-Labeled Antiobesity Agent Ro23-7637.

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journal contribution
posted on 2002-04-17, 00:00 authored by James D. White, Paul R. Blakemore, Selena Milicevic, Satish C. Choudhry, Joseph Cupano, Lucia Serico
Carbamates of primary and secondary amines react with the dianion of methyl phenyl sulfone to yield amidosulfones. Alylation of the amidosulfone followed by reductive removal of the sulfonyl residue gives an amide.