Conversion of Carbamates to
Amidosulfones and Amides. Synthesis
of the [14C]-Labeled Antiobesity Agent
Ro23-7637.

White, James D.; Blakemore, Paul R.; Milicevic, Selena; Choudhry, Satish C.; Cupano, Joseph; Serico, Lucia

doi:10.1021/ol020062p.s001

ol020062p_si_001.pdf (280.2 kB)

Conversion of Carbamates to Amidosulfones and Amides. Synthesis of the [¹⁴C]-Labeled Antiobesity Agent Ro23-7637.

journal contribution

posted on 2002-04-17, 00:00 authored by James D. White, Paul R. Blakemore, Selena Milicevic, Satish C. Choudhry, Joseph Cupano, Lucia Serico

Carbamates of primary and secondary amines react with the dianion of methyl phenyl sulfone to yield amidosulfones. Alylation of the amidosulfone followed by reductive removal of the sulfonyl residue gives an amide.

Conversion of Carbamates to Amidosulfones and Amides. Synthesis of the [¹⁴C]-Labeled Antiobesity Agent Ro23-7637.

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Conversion of Carbamates to Amidosulfones and Amides. Synthesis of the [14C]-Labeled Antiobesity Agent Ro23-7637.

History

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Read the peer-reviewed publication

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Conversion of Carbamates to Amidosulfones and Amides. Synthesis of the [¹⁴C]-Labeled Antiobesity Agent Ro23-7637.