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Convergent Synthesis of Digalactosyl Diacylglycerols

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journal contribution
posted on 2017-11-28, 17:46 authored by Shinsuke Inuki, Junichiro Kishi, Emi Kashiwabara, Toshihiko Aiba, Yukari Fujimoto
Efficient convergent chemical syntheses of digalactosyl diacylglycerols (DGDGs), which have both a galactose–galactose α(1→6)-linkage and a galactose–glycerol β-linkage along with a diacylglycerol containing various kinds of fatty acids, have been accomplished. In order to achieve a concise synthesis, we chose to use allylic protective groups as permanent protective groups. We have also achieved α- and β-selective glycosylations for the respective linkages with high yields as the key steps.

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