Convenient Synthesis of N-Unprotected Deoxynucleoside 3‘-Phosphoramidite Building Blocks by Selective Deacylation of N-Acylated Species and Their Facile Conversion to Other N-Functionalized Derivatives

A new route to N-unprotected deoxynucleoside 3‘-phosphoramidite building blocks by use of highly selective N-deacylation of commercially available N-acylated deoxynucleoside 3‘-phosphoramidites is described. These compounds could be readily converted to other types of N-protected species by facile N-acylations with acylating reagents.