Convenient Access to New Chiral Ferroceno-(iso)quinolines

New chiral pyridine derivatives possessing the planar chirality of the ferrocene have been prepared by means of an aldolization−crotonization reaction. This very simple reaction has been applied to the synthesis of isomers 1−4 that differ in the position of the nitrogen atom on the pyridine ring. Following the same procedure, asymmetric synthesis of 1 has been achieved using an enantiopure ferrocenylzinc intermediate. This method has also allowed the preparation of a chiral analogue of 2,2‘-bipyridine.