Controlled Oxidation of Pyrroles: Synthesis of Highly Functionalized γ‑Lactams

Howard, James K.; J. T. Hyland, Christopher; Just, Jeremy; Smith, Jason A.

doi:10.1021/ol400491p.s001

ol400491p_si_001.pdf (1.23 MB)

Controlled Oxidation of Pyrroles: Synthesis of Highly Functionalized γ‑Lactams

journal contribution

posted on 2016-02-19, 13:39 authored by James K. Howard, Christopher J. T. Hyland, Jeremy Just, Jason A. Smith

The oxidation of pyrroles usually leads to uncontrolled polymerization and decomposition. To overcome this problem, the controlled oxidation of substituted pyrroles with Dess-Martin periodinane is reported. This strategy yields a range of 5-aroyloxypyrrolinones.