American Chemical Society
ol400491p_si_001.pdf (1.23 MB)

Controlled Oxidation of Pyrroles: Synthesis of Highly Functionalized γ‑Lactams

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journal contribution
posted on 2016-02-19, 13:39 authored by James K. Howard, Christopher J. T. Hyland, Jeremy Just, Jason A. Smith
The oxidation of pyrroles usually leads to uncontrolled polymerization and decomposition. To overcome this problem, the controlled oxidation of substituted pyrroles with Dess-Martin periodinane is reported. This strategy yields a range of 5-aroyloxypyrrolinones.