Controlled Oxidation of Pyrroles: Synthesis of Highly Functionalized γ‑Lactams

Howard, James K.; J. T. Hyland, Christopher; Just, Jeremy; Smith, Jason A.

doi:10.1021/ol400491p.s001

Controlled Oxidation of Pyrroles: Synthesis of Highly Functionalized γ‑Lactams

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posted on 2016-02-19, 13:39 authored by James K. Howard, Christopher J. T. Hyland, Jeremy Just, Jason A. Smith

The oxidation of pyrroles usually leads to uncontrolled polymerization and decomposition. To overcome this problem, the controlled oxidation of substituted pyrroles with Dess-Martin periodinane is reported. This strategy yields a range of 5-aroyloxypyrrolinones.

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strategy yields aroyloxypyrrolinone pyrrole polymerization decomposition Synthesi oxidation periodinane LactamsThe Functionalized Pyrrole problem Controlled Oxidation

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Controlled Oxidation of Pyrroles: Synthesis of Highly Functionalized γ‑Lactams

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